Procedure Description:
Plasma Protein Concentrate (PPC) therapy is an advanced regenerative treatment derived from a patient’s own blood. Unlike traditional platelet-rich plasma (PRP), PPC isolates and concentrates specific bioactive proteins—such as albumin, fibronectin, vitronectin, IL1-RA and alpha-2 macroglobulin (A2M)—that play a key role in reducing inflammation, inhibiting cartilage degradation, and supporting tissue recovery. PPC is a cell-free, anti-inflammatory biologic designed for precision healing in degenerative and inflammatory musculoskeletal conditions.
What It Treats:
PPC is particularly beneficial for patients with:
Osteoarthritis (knee, shoulder, hip, etc.)
Degenerative disc disease
Chronic joint pain
Tendinopathies or ligament injuries
Failed response to traditional PRP or steroid injections
Early-stage cartilage degeneration
How It Is Performed:
Blood Collection: A small amount of blood (typically 60–120 mL) is drawn from the patient.
Laboratory Processing: The blood is processed in a specialized filtration system to isolate plasma proteins while removing platelets, white cells, and red cells.
Concentrate Preparation: The final product is a cell-free, highly concentrated protein solution rich in anti-inflammatory and cartilage-protective proteins like A2M.
Injection: The PPC is injected under ultrasound or fluoroscopic guidance into the targeted joint or soft tissue area.
Total Time: The procedure generally takes 30–45 minutes.
Pre-Procedure Instructions:
To prepare for the procedure:
Avoid NSAIDs (e.g., ibuprofen, naproxen) for 5–7 days before the procedure.
Stay well hydrated and eat a light meal on the day of your appointment.
Inform your provider of any blood-thinning medications or supplements you are taking.
Wear comfortable clothing that allows access to the treatment area.
Arrange transportation if sedation is being used (rarely necessary).
What to Expect After the Procedure:
Mild soreness or stiffness at the injection site may occur and typically resolves in a few days.
Avoid strenuous activity or heavy lifting involving the treated area for 1–2 weeks.
Do not use anti-inflammatory medications (unless directed) for at least 7 days after the procedure to preserve the action of the plasma proteins.
Use ice sparingly in the first 24–48 hours for comfort if needed.
Physical therapy may be recommended to enhance long-term outcomes.
Clinical improvement often begins within 2–6 weeks, with peak benefits occurring over several months.
Note: PPC therapy is autologous (derived from your own blood), minimizing risk of immune reaction or disease transmission. It is considered safe and well-tolerated, with minimal side effects.
To find out whether PPC is the right option for your joint or spine condition, schedule a consultation with our regenerative medicine team.
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